In 14 days, the 12 Hyaluronic Acids contained in Fillerina play their fundamental action for skin filling and volumisation by performing a FILLER effect on skin depressions (wrinkles, furrows and sagging facial features), and on the areas to be intensified such as cheekbones and lips.

Ex vivo and in vivo efficacy tests demonstrate the excellent results that can be reached with the application of hyaluronic acid molecules, capable to penetrate the skin by passing through the skin layers thanks to their diversified molecular weights.

In particular, the in vivo study on Fillerina, carried out on 40 women under double-blind, placebo-controlled conditions, was the subject of a scientific publication in the authoritative JOURNAL OF COSMETIC DERMATOLOGY, published by Wiley, one of the most important international scientific publishers. This magazine is the official agency of the International Academy of Cosmetic Dermatology based in Philadelphia, USA.

THE RESULTS OF THE CLINICAL-INSTRUMENTAL STUDY

Wrinkle Depth Reduction

The treatment with Fillerina active products determines a reduction equal to -8.4%, -14.5% and -21.8% in wrinkle depth, respectively after 7, 14 and 30 days of treatment. 95% of the subjects had positive results at 14 and 30 days.

Average result: -21.8%
Maximum result: -54.8%

Wrinkle Volume Reduction

The treatment with Fillerina active products results in an average reduction in wrinkle volume equal to -11.3%, -18.4% and -26.3% respectively after 7, 14 and 30 days of treatment. 95% of the subjects had positive results at 14 and 30 days.

Average result: -26.3%
Maximum result: -48.1%

Increase in Cheekbones Volume

The data measure the variation in the distance between the contours of the cheekbones and a line passing through the nose, expressed in millimeters.

Average result: +2.27 mm
Maximum result: +3.39 mm

Lifting of the Cheekbones

The Lifting of the Cheekbones measures the reduction in the distance between the contours of the cheekbones and a horizontal line intersecting the eyes, and is expressed in millimeters.

Average result: -2.51 mm
Maximum result: -3.67 mm

Lifting of the Facial Features

The data measure the distance between the upper part (forehead) and the lower part of the face (jaw) in 5 points and are expressed in millimeters. Negative number = reduction in the distance = remodeling action on the oval of the face.

Average result: -1.32 mm
Maximum result: -2.87 mm

Increase in Lip Volume

The plumping effect on the lips has been calculated based on the mathematical interpolation of the following parameters: 1) length of the labial rim, 2) height of the upper lip and 3) height of the lower lip.

Average result: +14.2%
Maximum result: +44.7%